Publications

2026

  1. PNAS
    Rat somatic genome editing enables ER+ breast cancer modeling
    W. Bu, T. D. Lee, M. Anurag, and 20 more authors
    Proc Natl Acad Sci U S A, 2026
  2. Nat Commun
    Extracellular matrix mediates circulating tumor cell clustering in triple-negative breast cancer metastasis
    G. O. M. Bobkov, K. J. Patel, B. M. Lege, and 4 more authors
    Nat Commun, 2026
  3. Cancer Res Commun
    Surface Marker Identification to Capture Live Circulating Tumor Cells in Metastatic Triple-Negative Breast Cancer
    B. M. Lege, K. J. Patel, B. Panici, and 4 more authors
    Cancer Res Commun, 2026

2025

  1. bioRxiv
    Rat somatic genome editing enables ER+ breast cancer modeling
    W. Bu, T. Lee, M. Anurag, and 17 more authors
    bioRxiv, 2025
  2. Cancer Discov
    Bone-Induced HER2 Promotes Secondary Metastasis in HR+/HER2- Breast Cancer
    R. Alam, A. Reva, D. G. Edwards, and 24 more authors
    Cancer Discov, 2025

2024

  1. Nat Rev Cancer
    Steering research on mRNA splicing in cancer towards clinical translation
    O. Anczukow, F. H. Allain, B. L. Angarola, and 16 more authors
    Nat Rev Cancer, 2024
  2. JBC
    PKC-mediated phosphorylation governs the stability and function of CELF1 as a driver of EMT in breast epithelial cells
    S. Massey, N. Kongchan, Y. Gao, and 7 more authors
    J Biol Chem, 2024
  3. PNAS Nexus
    Death-associated protein kinase 3 modulates migration and invasion of triple-negative breast cancer cells
    J. Wang, A. M. Tran-Huynh, B. J. Kim, and 14 more authors
    PNAS Nexus, 2024
  4. Mol Cell
    hnRNPM protects against the dsRNA-mediated interferon response by repressing LINE-associated cryptic splicing
    R. Zheng, M. Dunlap, G. O. M. Bobkov, and 15 more authors
    Mol Cell, 2024
  5. Cytotherapy
    Human platelet lysate enhances in vivo activity of CAR-Vdelta2 T cells by reducing cellular senescence and apoptosis
    F. Mo, C. T. Tsai, R. Zheng, and 5 more authors
    Cytotherapy, 2024
  6. Cells Tissues Organs
    Twenty Years of Epithelial-Mesenchymal Transition: A State of the Field from TEMTIA X
    P. Savagner, T. Brabletz, C. Cheng, and 6 more authors
    Cells Tissues Organs, 2024

2023

  1. Mol Ther
    Feasibility and preclinical efficacy of CD7-unedited CD7 CAR T cells for T cell malignancies
    N. Watanabe, F. Mo, R. Zheng, and 16 more authors
    Mol Ther, 2023

2022

  1. Leukemia
    Alternatively spliced CSF3R isoforms in SRSF2 P95H mutated myeloid neoplasms
    B. A. Wang, H. M. Mehta, S. R. Penumutchu, and 6 more authors
    Leukemia, 2022
  2. Cells Tissues Organs
    Regulation of Alternative Splicing during Epithelial-Mesenchymal Transition
    J. Lyu and C. Cheng
    Cells Tissues Organs, 2022

2021

  1. Methods Mol Biol
    Methods for Characterization of Alternative RNA Splicing
    S. E. Harvey, J. Lyu, and C. Cheng
    In , 2021
  2. Cell
    The bone microenvironment invigorates metastatic seeds for further dissemination
    W. Zhang, I. L. Bado, J. Hu, and 22 more authors
    Cell, 2021

2020

  1. Genome Biol
    RNA editing in cancer impacts mRNA abundance in immune response pathways
    T. W. Chan, T. Fu, J. H. Bahn, and 5 more authors
    Genome Biol, 2020
  2. RNA
    A combinatorially regulated RNA splicing signature predicts breast cancer EMT states and patient survival
    Y. Qiu, J. Lyu, M. Dunlap, and 2 more authors
    RNA, 2020
  3. Nat Commun
    The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing
    X. Hu, S. E. Harvey, R. Zheng, and 6 more authors
    Nat Commun, 2020

2019

  1. NAR
    A high-throughput screen identifies small molecule modulators of alternative splicing by targeting RNA G-quadruplexes
    J. Zhang, S. E. Harvey, and C. Cheng
    Nucleic Acids Res, 2019
  2. Genes Dev
    CD44 splice isoform switching determines breast cancer stem cell state
    H. Zhang, R. L. Brown, Y. Wei, and 11 more authors
    Genes Dev, 2019

2018

  1. PNAS
    DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer
    R. Matsunuma, D. W. Chan, B. J. Kim, and 13 more authors
    Proc Natl Acad Sci U S A. Epub 2018 Nov 29. PMID: 30498031 , Dec 2018
  2. RNA
    Co-regulation of alternative splicing by hnRNPM and ESRP1 during EMT
    S. E. Harvey, Y. Xu, X. Lin, and 5 more authors
    RNA, 2018
  3. BMC Biol
    Comparative analysis of single-stranded DNA donors to generate conditional null mouse alleles
    D. G. Lanza, A. Gaspero, I. Lorenzo, and 12 more authors
    BMC Biol, 2018

2017

  1. Genes Dev
    RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF
    H. Huang, J. Zhang, S. E. Harvey, and 2 more authors
    Genes Dev, 2017
  2. Oncotarget
    The non-canonical ubiquitin activating enzyme UBA6 suppresses epithelial-mesenchymal transition of mammary epithelial cells
    X. Liu, L. Sun, D. B. Gursel, and 6 more authors
    Oncotarget, 2017
  3. PNAS
    Internalized CD44s splice isoform attenuates EGFR degradation by targeting Rab7A
    W. Wang, H. Zhang, S. Liu, and 9 more authors
    Proc Natl Acad Sci U S A, 2017
  4. Cancer Res
    Akt signaling is sustained by a CD44 splice isoform-mediated positive feedback loop
    S. Liu and C. Cheng
    Cancer Res, 2017

2016

  1. J Cell Sci
    The CD44s splice isoform is a central mediator for invadopodia activity
    P. Zhao, Y. Xu, Y. Wei, and 4 more authors
    J Cell Sci, 2016
  2. Methods Mol Biol
    Methods for characterization of alternative RNA splicing
    S. E. Harvey and C. Cheng
    Methods Mol Biol, 2016

2014

  1. PNAS
    NanoFlares for the detection, isolation, and culture of live tumor cells from human blood
    T. L. Halo, K. M. McMahon, N. L. Angeloni, and 9 more authors
    Proc Natl Acad Sci U S A, 2014
  2. JoVE
    Detection of alternative splicing during epithelial-mesenchymal transition
    H. Huang, Y. Xu, and C. Cheng
    J Vis Exp, 2014
  3. Genes Dev
    Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing
    Y. Xu, X. D. Gao, J. H. Lee, and 11 more authors
    Genes Dev, 2014

2013

  1. WIREs RNA
    Alternative RNA splicing and cancer
    S. Liu and C. Cheng
    Wiley Interdiscip Rev RNA, 2013

2012

  1. JBC
    Snail represses the splicing regulator epithelial splicing regulatory protein 1 to promote epithelial-mesenchymal transition
    L. M. Reinke, Y. Xu, and C. Cheng
    J Biol Chem, 2012

2011

  1. JCI
    CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression
    R. L. Brown, L. M. Reinke, M. S. Damerow, and 4 more authors
    J Clin Invest, 2011